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Resources » Paper

Papaioannou S et al. (2008) Acta Biol Hung "The actions of Caenorhabditis elegans neuropeptide-like peptides (NLPs) on body wall muscle of Ascaris suum and pharyngeal muscle of C. elegans."

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  • Comments on Papaioannou S et al. (2008) Acta Biol Hung "The actions of Caenorhabditis elegans neuropeptide-like peptides (NLPs) on body wall muscle of Ascaris suum and pharyngeal muscle of C. elegans." (0)

  • Overview

    PMID:
    18652392
    DOI:
    10.1556/ABiol.59.2008.Suppl.28
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00032053

    Papaioannou S, Holden-Dye L, & Walker RJ (2008). The actions of Caenorhabditis elegans neuropeptide-like peptides (NLPs) on body wall muscle of Ascaris suum and pharyngeal muscle of C. elegans. Acta Biol Hung, 59 Suppl, 189-97. doi:10.1556/ABiol.59.2008.Suppl.28

    The actions of six Neuropeptide-like Peptides (NLPs) were investigated on Ascaris suum dorsal body wall muscle and Caenorhabditis elegans pharyngeal muscle. The NLPs tested on A. suum muscle, viz, NLP-1A, NLP-2A and B, had no direct effect on the muscle but all reversibly reduced acetylcholine (ACh)-induced contractions of the muscle, NLP-2A being the most potent, with an IC50 value of 78 microM. NLP-2A also reversibly reduced ACh-induced depolarizations of A. suum muscle resting membrane potential. NLP-1A, NLP-2A, NLP-3C and NLP-10A all increased pharyngeal pumping in C. elegans, NLP-8A weakly inhibited pumping while NLP-2B was inactive. NLP-10A induced a concentration-dependent increase in pumping activity with a threshold of 10-100 nM. Since genes encoding NLPs (nlp genes) are expressed in C. elegans pharyngeal neurons it is likely these peptides play a role in feeding behaviour.


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