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Resources » Paper

Son T. Le et al. (2008) "Functional characterization of dhs-21 in C. elegans"

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    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00031721

    Son T. Le, Kyung M. Ko, & Joohong Ahnn (2008). Functional characterization of dhs-21 in C. elegans presented in a meeting. Unpublished information; cite only with author permission.

    "C. elegans dhs-21 is predicted to encode a short chain dehydrogenase reductase (SDR/XDR). It has homologs in mouse, rat and human. They are highly conserved in functional domains.In C. elegan, DHS-21 is expressed in the intestine, hypodermis, uterus and spermatheca, and in mammals, its homologs are expressed in kidney cells. They probably inter-convert L-xylitol into xylitol in mammals and play a role in osmotic regulation. We have isolated a deletion mutant of dhs-21. dhs-21 (jh129) mutants exhibit decreased brood size, shorter life span compared to the wild type N2 worms. We are currently characterizing the genetic pathway related to regulation of dhs-21, which contributes to the life span and brood size in C. elegans."


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