Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Sun Y et al. (2006) Neurosci Bull "Computational analysis of genetic loci required for synapse structure and function and their corresponding microRNAs in C. elegans."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Sun Y et al. (2006) Neurosci Bull "Computational analysis of genetic loci required for synapse structure and function and their corresponding microRNAs in C. elegans." (0)

  • Overview

    PMID:
    17690719
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00030937

    Sun Y, Zhao YN, & Wang DY (2006). Computational analysis of genetic loci required for synapse structure and function and their corresponding microRNAs in C. elegans. Neurosci Bull, 22, 339-49.

    Objective To elucidate the important functions of microRNAs (miRNAs) in regulating synaptic assembly and function, we performed a computational analysis for the genetic loci required for the synaptic structure and function and their corresponding miRNAs in C. elegans. Methods Total 198 genetic loci required for the synaptic structure and function were selected. Sequence alignment was combined with E value evaluation to investigate and identify the possible corresponding miRNAs. Results Total 163 genes among the 198 genetic loci selected have their possibly corresponding regulatory miRNA (s), which covered most of the important genetic loci required for the synaptic structure and function. Moreover, only 22 genes among the analyzed 38 genetic loci encoding synaptic proteins have more possibility to under the control of non-coding RNA genes. In addition, the distribution of miRNAs along the 3' untranslated region (UTR) of these 22 genes exhibits different patterns. Conclusion Here we provide the computational screen and analysis results for the genetic loci required for synaptic structure and function and their possible corresponding miRNAs. These data will be useful for the further attempt to systematically determine the roles of miRNAs in synaptic assembly and function regulation in worms.


    Tip: Seeing your name marked red? Please help us identify you.