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Resources » Paper

Deng H et al. (2007) Dev Biol "Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5."

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  • Comments on Deng H et al. (2007) Dev Biol "Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5." (0)

  • Overview

    PMID:
    17574230
    DOI:
    10.1016/j.ydbio.2007.05.021
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00030771

    Deng H, Sun Y, Zhang Y, Luo X, Hou W, Yan L, Chen Y, Tian E, Han J, & Zhang H (2007). Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5. Dev Biol, 308, 583-92. doi:10.1016/j.ydbio.2007.05.021

    The C. elegans Hox gene egl-5 (ortholog of Drosophila Abdominal-B) is expressed in multiple tissues in the tail region and is involved in tail patterning. In this study, we identify and clone the corresponding C. elegans orthologs of the components of the heterotrimeric transcription factor NFY, nfya-1, nfyb-1 and nfyc-1 and demonstrate that mutations in these components result in the ectopic expression of egl-5 outside of its normal expression domains. The NFYA-1 protein forms a complex with NFYB-1 and NFYC-1, specifically recognizing the CCAAT box. Mutating a CCAAT box in the proximal promoter of egl-5 also leads to the derepression of egl-5, suggesting a direct role for the NFY complex in the regulation of egl-5. In addition, we show that the NFY complex interacts with the MES-2/MES-6 PcG complex in Hox gene regulation. Thus, our studies unravel a physiological function of NFY in establishing the spatially restricted expression pattern of egl-5.

    Authors: Deng H, Sun Y, Zhang Y, Luo X, Hou W, Yan L, Chen Y, Tian E, Han J, Zhang H


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