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Resources » Paper

Hongtao Jia et al. (2007) International Worm Meeting "Characterizing of an apoptotic role for EGL-38 in germline cell in C. elegans ."

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  • Comments on Hongtao Jia et al. (2007) International Worm Meeting "Characterizing of an apoptotic role for EGL-38 in germline cell in C. elegans ." (0)

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    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00030418

    Hongtao Jia, DonHa Park, & Helen Chamberlin (2007). Characterizing of an apoptotic role for EGL-38 in germline cell in C. elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    In C. elegans, the core apoptotic pathway which influences both radiation-induced DNA damage cell death and physiological germ cell death has been well characterized. However, it is less well known what signals trigger apoptosis, and how these signals are transduced to the core apoptotic elements. In our previous studies, we have found that two Pax2/5/8 genes, egl-38 and pax-2, can regulate cell survival in C. elegans2. Using genetic and molecular analysis, we showed that the Pax2/5/8 proteins promote cell survival by regulating the Bcl-2 gene ced-9. We are interested in understanding how these Pax2/5/8 proteins function with respect to other pathways that influence cell survival. Others have shown that germ cell apoptosis in C. elegans requires the Ras pathway 1. Our genetic epistasis studies suggest that egl-38/pax-2 act either downstream of or in parallel to the Ras pathway in this tissue. We are interested in testing the possibility that the Ras pathway may influence cell survival by regulating Pax2/5/8 protein function. We have found that ced-9 mRNA abundance is increased in mpk-1 mutants, suggesting that the Ras pathway may influence cell survival through the same mechanism as egl-38 and pax-2. We have also found that the Pax2/5/8 protein DNA binding domain can be phosphorylated by C. elegans MAP kinase MPK-1 homolog ERK-1 in vitro. Mutating potential phosphorylation site in the Pax DNA binding domain can completely abolish its phosphorylation. The in vivo functional relationship between the Ras pathway and Pax2/5/8 proteins is being tested. References 1. Gumienny, T. L., Lambie, E., Hartwieg, E., Horvitz, R. H. and Hengartner, M. O. 1999. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development 126: 1011-1022. 2. Park, D., Jia, H., Rajakumar, V. and Chamberlin, H.M. 2006. Pax/2/5/8 proteins promote cell survival in C. elegans. Development 133: 4193-4202.


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