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Resources » Paper

Marion RM et al. (2004) Proc Natl Acad Sci U S A "Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression."

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  • Comments on Marion RM et al. (2004) Proc Natl Acad Sci U S A "Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression." (0)

  • Overview

    PMID:
    15353587
    DOI:
    10.1073/pnas.0405353101
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00028831

    Marion RM, Regev A, Segal E, Barash Y, Koller D, Friedman N, & O'Shea EK (2004). Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proc Natl Acad Sci U S A, 101, 14315-22. doi:10.1073/pnas.0405353101

    Yeast cells modulate their protein synthesis capacity in response to physiological needs through the transcriptional control of ribosomal protein (RP) genes. Here we demonstrate that the transcription factor Sfp1, previously shown to play a role in the control of cell size, regulates RP gene expression in response to nutrients and stress. Under optimal growth conditions, Sfp1 is localized to the nucleus, bound to the promoters of RP genes, and helps promote RP gene expression. In response to inhibition of target of rapamycin (TOR) signaling, stress, or changes in nutrient availability, Sfp1 is released from RP gene promoters and leaves the nucleus, and RP gene transcription is down-regulated. Additionally, cells lacking Sfp1 fail to appropriately modulate RP gene expression in response to environmental cues. We conclude that Sfp1 integrates information from nutrient- and stress-responsive signaling pathways to help control RP gene expression.


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