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Resources » Paper

Paschinger, K et al. (2005) Acta Biochimica Polonica "Definition of immunogenic carbohydrate epitopes."

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    PMID:
    16175237
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00026889

    Paschinger, K, Fabini, G, Schuster, D, Rendic, D, & Wilson, IBH (2005). Definition of immunogenic carbohydrate epitopes. Acta Biochimica Polonica, 52, 629-632.

    Carbohydrates are known as sources of immunological cross-reactivity of allergenic significance. In celery and in cypress pollen, the major allergens Api g 5 and Cup a 1 are recognised by antisera raised against anti-horseradish peroxidase and by patients'''' IgE which apparently bind carbohydrate epitopes; mass spectrometric analysis of the tryptic peptides and of their N-glycans showed the presence of oligosaccharides carrying both xylose and core alpha 1,3-fucose residues. Core alpha 1,3-fucose residues are also a feature of invertebrates: genetic and biochemical studies on the fruitfly Drosophila melanogaster, the parasitic trematode Schistosoma mansoni and the nematode worm Caenorhabditis elegans indicate that these organisms possess core alpha 1,3-fucosyltransferases. Various experiments have shown that fucosyltransferases from both fly and worm are responsible in vivo and in vitro for the synthesis of N-glycans which cross-react with anti-horseradish peroxidase; thus, we can consider these enzymes as useful tools in generating standard compounds for testing cross-reactive carbohydrate epitopes of


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