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Resources » Paper

Matsumoto M et al. (2005) Cell Metab "All roads lead to FoxO."

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  • Overview

    PMID:
    16054064
    DOI:
    10.1016/j.cmet.2005.03.008
    Status:
    Publication type:
    Comment
    WormBase ID:
    WBPaper00026658

    Matsumoto M, & Accili D (2005). All roads lead to FoxO. Cell Metab, 1, 215-6. doi:10.1016/j.cmet.2005.03.008

    Stress-activated kinases control metabolism by antagonizing the early steps of insulin signal transduction. Two papers now demonstrate that Jnk, the prototypical stress-activated kinase, controls life span in Drosophila and C. elegans by promoting phosphorylation of the forkhead protein FoxO (Oh et al., 2005; Wang et al., 2005). The findings provide yet another mechanism by which metabolic and stress responses are integrated via phosphorylation of FoxO proteins.


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