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Resources » Paper

Yoko Honda et al. (2005) International Worm Meeting "Effects of the gene disruption of SOD on stress resistance, development and lifespan in Caenorhabditis elegans"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00025847

    Yoko Honda, & Shuji Honda (2005). Effects of the gene disruption of SOD on stress resistance, development and lifespan in Caenorhabditis elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Insulin/IGF-I signaling controls stress resistance and development as well as aging in C. elegans. We found that the expression of sod-3, one of two Mn superoxide dismutase (SOD) isoform genes (sod-2 and sod-3), was much higher in insulin/IGF-I receptor (DAF-2) mutants (1) and phosphatidyl inositol 3 kinase (AGE-1) mutants (2) than in N2. To elucidate the function of MnSODs in the control by insulin/IGF-I signaling, the effects of MnSOD gene deletions in the background of daf-2 mutants on stress resistance, lifespan and dauer formation were examined. The severity of oxidative-stress sensitivity was as follows: N2 < sod-3 < sod-2 < sod-2; sod-3. However, the deletion of sod-2 or sod-3 gene does not affect oxidative-stress resistance in daf-2 mutant, although oxidative-stress resistance was totally abrogated in the triple mutant: sod-2; daf-2; sod-3. The lifespan of sod-2; daf-2 double mutant and sod-2; daf-2; sod-3 triple mutant were longer than N2 but were slightly shorter than that of daf-2, while that of daf-2; sod-3 double mutant was longer than that of daf-2. These findings indicated that oxidative-stress resistance did not correlate with lifespan extension in daf-2 mutants upon MnSOD disruption. The effects of the sod deletions on dauer formation in daf-2 were examined. The relationship between reactive oxygen species and development and aging will be discussed.(1) Honda Y, Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13:1385-1393. 1999(2) Honda Y, Honda S. Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabditis elegans; Studies of mutation in the age-1, PI3 kinase homologue and short-term exposure to hyperoxia. J. Amer. Aging Assoc. 24: 179-186. 2001

    Affiliation:
    - Tokyo Metropolitan Institute of Gerontology, Tokyo, JAPAN


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