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Resources » Paper

Jodie F Wren et al. (2005) International Worm Meeting "Environmental Genomics of Fluoranthene Exposure"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00025549

    Jodie F Wren, Suresh C Swain, Martijs J Jonker, Nick Redshaw, Peter K Hankard, Claus Svendsen, David J Spurgeon, A John Morgan, & Stephen R Sturzenbaum (2005). Environmental Genomics of Fluoranthene Exposure presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Benzo(j)Fluoranthene, is a 5-ring polycyclic aromatic hydrocarbon (PAH), known to occur as a product of plant biosynthesis, but also as a byproduct of incomplete combustion of organic material. Fluoranthene has been identified in cigarette smoke, char-broiled foods, drinking water, lake sediments and ambient air. It is thought to interact with DNA, cause heritable genetic disorders and has been associated with lung, intestinal and pharyngeal cancer. Information regarding the toxicity of fluoranthene in C.elegans still remains scarce, a shortfall we are aiming to redress. Using GE-31 (an embryonic lethal TS mutant) an elaborate toxicity test identified a dose dependant slippery pharynx phenotype and effects on specific demographic endpoints, such as brood size, volumetric growth and life span. Exploiting whole genome oligo array technology, we are currently exploring the stage-specific toxic effects of fluoranthene at a transcriptional level.

    Authors: Jodie F Wren, Suresh C Swain, Martijs J Jonker, Nick Redshaw, Peter K Hankard, Claus Svendsen, David J Spurgeon, A John Morgan, Stephen R Sturzenbaum

    Affiliations:
    - Centre for Ecology & Hydrology, Monks Wood, Abbots Ripton, PE28 2LS, U.K.
    - Cardiff School of Biosciences, Cardiff University, PO Box 915, CF10 3TL, U.K.


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