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Resources » Paper

Parker JA et al. (2005) Nat Genet "Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons."

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  • Comments on Parker JA et al. (2005) Nat Genet "Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons." (0)

  • Overview

    PMID:
    15793589
    DOI:
    10.1038/ng1534
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00025055

    Parker JA, Arango M, Abderrahmane S, Lambert E, Tourette C, Catoire H, & Neri C (2005). Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet, 37, 349-50. doi:10.1038/ng1534

    We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.


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