Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Leroi AM et al. (2005) Mechanisms of Ageing & Development "What evidence is there for the existence of individual genes with antagonistic pleitropic effects?"

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Leroi AM et al. (2005) Mechanisms of Ageing & Development "What evidence is there for the existence of individual genes with antagonistic pleitropic effects?" (0)

  • Overview

    PMID:
    15664630
    DOI:
    10.1016/j.mad.2004.07.012
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00024991

    Leroi AM, Bartke A, De Benedictis G, Franceschi C, Gartner A, Gonos E, Feder ME, Kivisild T, Lee S, Kartal-Ozer N, Schumacher M, Sikora E, Slagboom E, Tatar M, Yashin AI, Vijg J, & Zwaan B (2005). What evidence is there for the existence of individual genes with antagonistic pleitropic effects?. Mechanisms of Ageing & Development, 126, 421-429. doi:10.1016/j.mad.2004.07.012

    Classical evolutionary theory predicts the existence of genes with antagonistic effects on longevity and various components of early-life fitness. Quantitative genetic studies have provided convincing evidence that such genes exist. However, antagonistic pleiotropic effects have rarely been attributed to individual loci. We examine several classes of longevity-assurance genes: those involved in regulation of the gonad; the insulin-like growth factor pathway; free-radical scavenging; heat shock proteins and apoptosis. We find initial evidence that antagonistic pleiotropic effects are pervasive in each of these classes of genes and in various model systems-although most studies lack explicit studies of fitness components. This is particularly true of human studies. Very little is known about the early-life fitness effects of longevity loci. Given the possible medical importance of such effects we urge their future study.

    Authors: Leroi AM, Bartke A, De Benedictis G, Franceschi C, Gartner A, Gonos E, Feder ME, Kivisild T, Lee S, Kartal-Ozer N, Schumacher M, Sikora E, Slagboom E, Tatar M, Yashin AI, Vijg J, Zwaan B


    Tip: Seeing your name marked red? Please help us identify you.