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Resources » Paper

H Nguyen et al. (1999) International C. elegans Meeting "Diplogasteroides berwigi: A model for the further phylogenetic analysis of nematode vulval evolution"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00023479

    H Nguyen, B Jungblut, & R Sommer (1999). Diplogasteroides berwigi: A model for the further phylogenetic analysis of nematode vulval evolution presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    Our lab is studying the evolution of developmental processes by comparing vulva development between C. elegans and Pristionchus pacificus . This cellular, genetic and molecular comparison links changes in cell fate specification to differences in the molecular mechanisms during development. Ultimately, comparative developmental biology has to consider not only the mechanistic but also the phylogenetic perspective. The identification of genes that have changed their function over long evolutionary timescales, such as C. elegans and P. pacificus can only be the first step. More detailed comparison at the phylogenetic level have to follow by studying more closely related species. Fortunately, molecular and morphological analyses provide us with detailed phylogenetic trees of nematodes. Based on the current phylogeny, several species can be selected for functional analysis. Here we describe our initial genetic and molecular work in Diplogasteroides berwigi , an ancestral member of the Diplogastridae. This hermaphroditic strain has a 5 day generation time and is accessible to genetic analysis. One of the aims of comparative genetics in this species is the functional comparison of mab-5 , a homeotic transcription factor, that has changed its function dramatically between P. pacificus and C. elegans . mab-5 cloning from D. berwigi and first mutant analysis is reported.


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