Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Spycher C et al. (1997) International C. elegans Meeting "A GROWING FAMILY OF PI3-KINASES IN C.ELEGANS ?"

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Spycher C et al. (1997) International C. elegans Meeting "A GROWING FAMILY OF PI3-KINASES IN C.ELEGANS ?" (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00022722

    Spycher C, Wymann MP, & Mueller F (1997). A GROWING FAMILY OF PI3-KINASES IN C.ELEGANS ? presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    Phosphoinositide 3-kinases (PI3Ks) have been found in mammals, yeasts, plants, Drosophila and Dictyostelium. They are involved in signal transduction and play a role in cellular processes like mitogenesis, cell growth, differentiation, actin-filament rearrangement, vesicular trafficking, glucose uptake and more. According to their in vitro substrate specificity and primary sequence, PI3Ks can be divided into three classes. In addition to them, there are PI3K-like proteins: ATM (ataxia telangiectasia mutated), DNA-dependent protein kinase (DNA-PKcs) and related genes contain a C-terminal catalytic domain similar to PIKs, but lipid phosphorylation activity has not been shown yet. The latter proteins seem to be involved in DNA repair processes and control of the cell-cycle. For some an intrinsic serine/threonine protein kinase activity has been demonstrated. Two PI3K family members have been identified so far in C.elegans. AGE-1 which controls dauer formation and lifespan (Morris et al., Nature 382, 536-539 (1996)) and a Vps34p homolog (our lab), which is needed for protein sorting to the yeast vacuole. We have recently initiated a search for more genes encoding PI3Ks and PI3K-like proteins in C.elegans. C.elegans database searches have identified promising candidates that are currently being analysed. Antisense-RNA injections shall be used to predict the phenotypes of defective mutants of the respective genes. Further studies will provide us with more information about their role in the development of a multicellular organism.

    Affiliation:
    - Institute of Zoology, University of Fribourg, Perolles, CH-1700 Fribourg, Switzerland


    Tip: Seeing your name marked red? Please help us identify you.