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Comments on Katsura I et al. (1997) International C. elegans Meeting "SYNTHETIC ABNORMALITY IN DAUER FORMATION, NEURAL CIRCUITS AND GENE FUNCTIONS" (0)
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Katsura I, Ishihara T, & Suzuki N (1997). SYNTHETIC ABNORMALITY IN DAUER FORMATION, NEURAL CIRCUITS AND GENE FUNCTIONS presented in International C. elegans Meeting. Unpublished information; cite only with author permission.
Neural mutations in more than 50 genes show synthetic dauer-constitutive (Sdf-c) phenotypes, while they are Daf+ or even Daf-d by themselves. Although there are many reasons for synthetic phenotypes in general, Sdf-c phenotypes seem to arise from parallel or netted pathways for dauer-regulatory signals in neural circuits. Thus, we can analyze the neural circuits of dauer regulation and the roles of gene functions in the circuits, using this phenomenon. The combinations of mutations showing Sdf-c phenotypes have a specific pattern and suggest that the dauer-regulatory signals can be divided into three parts: two of them are signals that depend on external stimuli including both pheromone and food, and one is a dauer-inhibitory signal that does not depend on sensory inputs. The last signal is probably the same as the dauer-inhibitory activity of ADF and ASI neurons, which Bargmann and Horvitz (1991) deduced from laser-killing experiments. We argue that this signal is blocked by unc-3, unc-31 or unc-104 mutations, where unc-3 and unc-31 also block part of the former signals. Our results on dauer formation in the presence of ketanserin (serotonin antagonist) as well as results of other laboratories suggest that the former two signals are provoked in ADF and ASI, respectively, by external stimuli. We tested suppression of various Sdf phenotypes by daf-3, daf-5, osm-1, tax-2, unc-86, and dpy-3. They showed distinct suppression patterns. We think that these experiments give information on the functional relationship between the Sdf-c and suppressor genes as well as the cells that are affected by the mutations.
Affiliation:
- National Institute of Genetics and Dept. of Genetics, Graduate University of Advanced Studies, Mishima, 411 Japan