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Resources » Paper

Downs WD et al. (1997) International C. elegans Meeting "THE GENE MOM-1 IMPLICATES A WNT/WINGLESS PATHWAY IN ESTABLISHING CELL POLARITY AND ASYMMETRIC LINEAGES IN C. ELEGANS"

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  • Comments on Downs WD et al. (1997) International C. elegans Meeting "THE GENE MOM-1 IMPLICATES A WNT/WINGLESS PATHWAY IN ESTABLISHING CELL POLARITY AND ASYMMETRIC LINEAGES IN C. ELEGANS" (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00022247

    Downs WD, Cha Y-H, Mello CC, & Priess JR (1997). THE GENE MOM-1 IMPLICATES A WNT/WINGLESS PATHWAY IN ESTABLISHING CELL POLARITY AND ASYMMETRIC LINEAGES IN C. ELEGANS presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    During the development of C. elegans, the majority of cell divisions are asymmetric, resulting in daughter cells that will assume different fates. Our work indicates that the gene mom-1 (MOre Mesoderm) is necessary to induce polarity in a cell that will lead to an asymmetry in its lineage. Two of these mom-1 dependent asymmetries rely upon cell signaling in C. elegans: 1) induction of the intestine in the 4-cell stage embryo (Goldstein, 1992) and 2) patterning of the vulva during postembryonic development (Katz & Sternberg, 1990). Cell signaling events involving glp-1/lin-12 (Notch-related), and lin-3 (EGF) mediated pathways remain operational in mom-1 mutants. However, the vulva defects observed in mom-1 mutants are also observed in loss of function alleles of lin-17, a gene previously implicated in wnt signaling in C. elegans and homologous to the putative Wingless receptor of Drosophila (Sawa & Horvitz, 1996). We have cloned the mom-1 gene and found that it is homologous to porcupine, a gene of the Drosophila wingless pathway. Based on these findings we now believe that mom-1 is acting through a wnt/wingless cell-signaling pathway.

    Affiliation:
    - Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Fred Hutchinson Cancer Research Center, Seattle, WA 98109, Howard Hughes Medical Institute University of Massachusetts Medical Center, Worcester, MA 01605 Fred Hutchinson Cancer Research Center, Seattle, WA 98109, Department of Zoology, University of Washington, Seattle, WA 98195, Howard Hughes Medical Institute


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