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C. elegans can be transformed efficiently with exogenous genetic material using the technique of microinjection (Mello et. al, 1991). Although microinjection is becoming easier and more economical through the use of devices like our $425 microINJECTOR System, the procedure relies on a microscope system and accessories costing between $10,000 and $30,000, as well as some dexterity and knowledge of worm anatomy.