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Resources » Paper

Seydoux GC et al. (1995) International C. elegans Meeting "GERM-CELL FATE IS LINKED TO REPRESSION OF TRANSCRIPTION IN EARLY C. ELEGANS EMBRYOS."

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00021850

    Seydoux GC, & Fire A (1995). GERM-CELL FATE IS LINKED TO REPRESSION OF TRANSCRIPTION IN EARLY C. ELEGANS EMBRYOS presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    The first cleavages of the C. elegans embryo are asymmetric and mark the step-wise separation of soma and germline. We have identified several differences between somatic and germline blastomeres during early cleavages (1) 1. Germline cells protect certain maternal RNAs from a rapid degradation which occurs in somatic cells. 2. Germline cells contain clusters of poly-A+ RNAs associated with the germline-specific P granules. These clusters are not seen in somatic cells. 3. As early as the four-cell stage, somatic cells transcribe certain RNAs, which are off in germline cells. So far, no transcribed gene has been identified in early germline blastomeres. An intriguing possibility is that these cells are transcriptionally inactive.


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