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Resources » Paper

Harris J et al. (1995) International C. elegans Meeting "GENES THAT DETERMINE THE DIRECTION OF MIGRATION AND FINAL POSITIONING OF MIGRATORY NEUROBLASTS."

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  • Comments on Harris J et al. (1995) International C. elegans Meeting "GENES THAT DETERMINE THE DIRECTION OF MIGRATION AND FINAL POSITIONING OF MIGRATORY NEUROBLASTS." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00021814

    Harris J, Honigberg LA, Robinson NT, & Kenyon CJ (1995). GENES THAT DETERMINE THE DIRECTION OF MIGRATION AND FINAL POSITIONING OF MIGRATORY NEUROBLASTS presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    How do the Q neuroblasts and their descendants know which direction to migrate and where to stop? QL and QR migrate in opposite directions, and their descendants stop at different positions along the body from the head to the tail. Our lab is studying genes required for left-right asymmetry, guidance and execution of Q cell migration. Four of these genes, egl-20, mig-14, mig-1, and lin-17, determine the direction of migration of the QL descendants. Two of these genes, egl-20 and mig-14, are also required to position the migrating cells correctly along the anterior/posterior (A/P) axis. We have shown that these four genes control the direction of Q neuroblast descendant migration by regulating the expression of the homeotic gene responsible for patterning the posterior body, the Antennapedia homolog mab-5. Genetic and molecular analysis shows that the QL descendants in these mutants fail to express mab-5 but are able to migrate towards the posterior if mab-5 is provided. In addition to their effect on mab-5 expression, egl-20 and mig-14 also act in a mab-5-independant way to position these migrating Q descendants along the A/P axis. Mutations in these genes cause the migrating Q descendants to seek positions posterior to their normal location, even if they must migrate in the opposite direction to do so. This makes egl-20 and mig-14 candidates for components of a system of positional information that determines the final positions of the Q descendants along the A/P body axis.


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