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Resources » Paper

Wang BB et al. (1991) International C. elegans Meeting "An update on the mab-5 complex"

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    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00021017

    Wang BB, & Kenyon CJ (1991). An update on the mab-5 complex presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    We are interested in determining whether C. elegans contains a complex of homeobox-containing genes similar to those found in Drosophila and in vertebrates. The order of the Drosophila homeotic selector genes in the Antennapedia and Bithorax complexes correlates with the order of their expression along the anterior-posterior axis of the embryo. Likewise, the vertebrate homologues of these genes are grouped into complexes and, as shown in the mouse, their chromosomal organization also correlates with their domains of expression. Previous work in our lab on mab-5, an Antp-like homeobox gene responsible for the normal specification of cells in the posterior body region, and more recent work by several labs on ceh-13, egl-5 and lin-39, suggest that a similar complex may exist in C. elegans ( discussed in Wang and Kenyon, WBG 11:5). The chromosomal positions and homeobox sequences of ceh-15, mab-5 and ceh-ll are analogous to the organization of homeobox genes in the Drosophila and vertebrate complexes. (WBG 11:5) We have now determined that ceh-13, a homeobox gene with lab-like homology (Schaller, et al., Nuc. Acids Res. 18:2033), is located to the left of ceh-15, also analogous to the organization in the Drosophila and vertebrate complexes. We are probing about 20 overlapping cosmids spanning the mab-5 region (mec-14 to egl-45) with degenerate homeobox-specific oligos described by Burglin, et al. (Nature 341:239) in order to identify more homeobox genes that may be a part of the mab-5 complex. Preliminary hybridization data suggest that there could be several additional Antp-like homeobox genes in the region.


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