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Resources » Paper

Claudia Morales et al. (2003) International Worm Meeting "Proteins that interact with the Hth/Meis homolog UNC-62"

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  • Comments on Claudia Morales et al. (2003) International Worm Meeting "Proteins that interact with the Hth/Meis homolog UNC-62" (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00019764

    Claudia Morales, Tassa Saldi, & William B Wood (2003). Proteins that interact with the Hth/Meis homolog UNC-62 presented in International Worm Meeting. Unpublished information; cite only with author permission.

    We have previously shown that different mutations in the unc-62 gene cause a variety of embryonic and larval defects, consistent with multiple roles in development, and that these mutations interact genetically with mutations in the ceh-20 and ceh-40 genes, which encode homologs of Exd/Pbx proteins (Van Auken et al. Development 129: 5255-5268, 2002). If UNC-62 functions similarly to its homologs Hth in Drosophila and Meis proteins in vertebrates, it might be expected to interact physically with posterior-group homeobox proteins, such as NOB-1, as well as with CEH-20 or CEH-40, or both. To test this prediction, we have made an UNC-62::6His fusion protein and prepared an affinity-purified antibody to it. We will report results of both co-immunoprecipitation and pull-down experiments to identify interacting proteins. We are also testing the antibody for in situ staining to obtain further information on unc-62 expression patterns.


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