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Resources » Paper

Coleen T Murphy et al. (2003) International Worm Meeting "Genes that act downstream of DAF-16 to influence C. elegans lifespan."

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  • Comments on Coleen T Murphy et al. (2003) International Worm Meeting "Genes that act downstream of DAF-16 to influence C. elegans lifespan." (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00019747

    Coleen T Murphy, Steven A McCarroll, Jason D Lieb, Cornelia I Bargmann, Ravi S Kamath, Andrew Fraser, Julie Ahringer, Hao Li, & Cynthia J Kenyon (2003). Genes that act downstream of DAF-16 to influence C. elegans lifespan presented in International Worm Meeting. Unpublished information; cite only with author permission.

    DAF-16, a FOXO-family transcription factor, influences the rate of aging of C. elegans in response to insulin/IGF-1 signaling. Using DNA microarray analysis, we found that DAF-16 affects the expression of a set of genes during early adulthood, the time at which this pathway is known to influence aging. We also found that many of these genes influence the aging process. Several of these genes are novel longevity factors, and we are currently working to characterize these processes in further detail. Additionally, we observed that both the canonical DAF-16 binding site and a novel sequence are overrepresented in the promoters of the daf-2-regulated genes. We are now performing chromatin IP microarray (ChIP/chip) experiments to distinguish direct and indirect DAF-16 targets. The insulin/IGF-1 pathway functions cell-nonautonomously to regulate lifespan, and our findings suggest that it signals other cells, at least in part, by feedback regulation of an insulin/IGF-1 homolog. Our findings suggest that the insulin/IGF-1 pathway ultimately exerts its effect on lifespan by up-regulating a wide variety of genes, including cellular stress-response and anti-microbial genes, and by down-regulating specific life-shortening genes.

    Authors: Coleen T Murphy, Steven A McCarroll, Jason D Lieb, Cornelia I Bargmann, Ravi S Kamath, Andrew Fraser, Julie Ahringer, Hao Li, Cynthia J Kenyon


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