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Resources » Paper

Ellen Batchelder et al. (2001) International C. elegans Meeting "Investigating the possibe role of calmodulin in cytokinesis"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00018066

    Ellen Batchelder, John White, & Jeff Walker (2001). Investigating the possibe role of calmodulin in cytokinesis presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    Cytokinesis, the physical separation of a cell during cell division, is fundamentally important to all cell types and must be tightly regulated. Both spatial and temporal regulation are required to ensure proper segregation of chromosomes and molecules involved in processes such as development and differentiation. Calmodulin is a good candidate for a regulator of cytokinesis. It has been localized to the cleavage furrow and/or mitotic apparatus in different organisms and is a known regulator in other calcium dependent pathways, through its calcium sensing properties. Our work has focused on determining the role of calmodulin in regulating cytokinesis in C. elegans using a combination of standard and novel techniques. There are several candidate calmodulins in the worm database, the most conserved of which is CMD-1. Surprisingly, RNAi experiments using cmd-1 did not show cytokinetic defects, although a dramatic embryonic arrest at morphogensis was observed. Other candidate calmodulins are currently being examined with RNAi. Localization studies are also underway. Additionally, we are attempting to phenocopy the RNAi results and to study calmodulin in a more temporally defined manner using a caged calmodulin inhibitor.


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