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Resources » Paper

Benny H H Cheung et al. (2001) International C. elegans Meeting "Genes regulating social feeding behaviour in C elegans."

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    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00017974

    Benny H H Cheung, & Mario De Bono (2001). Genes regulating social feeding behaviour in C elegans presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    Natural isolates of C. elegans exhibit either social or solitary feeding behaviour. Social strains aggregate and feed together on a bacterial lawn; solitary strains show no aggregation and feed in isolation. This variation is due to a single amino acid change in NPR-1, a seven transmembrane receptor related to mammalian neuropeptide Y receptors. Null mutations in npr-1 transform solitary wild strains into strongly social animals. We wish to elucidate the molecular pathways controlling social versus solitary feeding. Two EMS mutagenesis screens have been performed, starting with strongly social npr-1 (null) animals in both N2 and CB4856 (a snip-SNP-bearing strain) backgrounds, and selecting for mutants that feed alone. About sixty mutations have been isolated thus far, which show varying degrees of suppression of social behaviour. Several known suppressors (e.g. odr-8 , osm-9 etc.), which function in other sensory pathways, have been pulled out from these two screens. Fifteen strong, novel suppressors have been chosen, mapped and characterised further. We hope these suppressors will identify molecules that either regulate the choice between social and solitary feeding, or are essential signal transduction components of the sensory inputs leading to social behaviour. Davis M.W. and Avery L.. Social Behavior in bor-1 Mutants Depends on Bacterial Smell. Worm Breeder's Gazette 11(5): 69. Cassada R.. Burrowing, Spontaneous Mutants, etc. with Another Wildtype Strain. Worm Breeder's Gazette 9(3): 29. Hodgkin J. and Doniach T. (1997). Natural variation and copulatory plug formation in Caenorhabditis elegans . Genetics 146: 149-164. de Bono M. and Bargmann C.I. (1998). Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans . Cell 94: 679-689.


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