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Resources » Paper

Joy Alcedo et al. (2001) International C. elegans Meeting "Role of sensory cilia and sensory neurons in the regulation of worm lifespan"

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    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00017917

    Joy Alcedo, Javier Apfeld, Bella Albinder, Jennifer Dorman, Honor Hsin, Bernadine Tsung, & Cynthia Kenyon (2001). Role of sensory cilia and sensory neurons in the regulation of worm lifespan presented in International C. elegans Meeting. Unpublished information; cite only with author permission.

    Worms with sensory defects live longer than normal worms, which suggests that the lifespan of C. elegans might be regulated by the perception of a signal(s) from the environment (Apfeld and Kenyon, (1999). Nature 402 , 804-809). One of the mutations isolated from an EMS lifespan screen performed by our lab is an allele of daf-10 , which is required for the normal development of the sensory cilia of the worm. daf-10 ( mu377 ) has a temperature-sensitive defect in its sensory cilia, which correlates with its temperature-sensitive lifespan phenotype. At the restrictive temperature, mu377 exhibits a defect in its sensory cilia and lives longer than wild-type worms, whereas at the permissive temperature, mu377 exhibits normal sensory cilia and normal lifespan. Since the defect in the sensory cilia of mu377 is reversible, we determined the temporal requirement for the gene product of mu377 in regulating worm lifespan by performing temperature-shift experiments. Our data suggest that the gene product of mu377 is required late in larval development for proper lifespan control. Furthermore, to gain insight into which of the sensory neurons of the worm are necessary to regulate its lifespan, we are ablating subsets of sensory neurons in wild-type or sensory mutant worms. We are also expressing wild-type sensory genes in subsets of mutant sensory neurons to determine which functional sensory neurons are sufficient to rescue the lifespan phenotype of sensory mutants. Since different sensory neurons sense different types of environmental cues, e.g. , attraction to or repulsion from volatile vs . soluble compounds, the identification of which sensory neurons control lifespan could provide insight into what type of environmental signal regulates animal lifespan.


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