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Resources » Paper

Rahmani P et al. (1998) West Coast Worm Meeting "CHARACTERIZATION OF THE unc-23 GENE IN C. ELEGANS"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00017375

    Rahmani P, & Moerman DG (1998). CHARACTERIZATION OF THE unc-23 GENE IN C. ELEGANS presented in West Coast Worm Meeting. Unpublished information; cite only with author permission.

    Mutations in the unc-23 gene result in progressive dystrophy of the anterior body wall musculature, giving rise to a bent-head phenotype. This phenotype is not observed when animals are grown in liquid culture (Bullerjahn and Riddle, pers. comm.). Neither muscle cell positioning nor myofilament assembly is affected in liquid grown unc-23 animals; muscle cell attachment, however, is affected since a small amount of stress applied results in detachment of the muscle cells from the hypodermis. These observations suggest that UNC-23 is involved in muscle cell attachment rather than myofilament lattice assembly. The results of immunological staining of unc-23 animals with antibodies to basement membrane and hypodermal components (GM1, perlecan; MH4, intermediate filaments; MH5, hemidesmosomes) suggest that the primary defect in unc-23 animals is located within the hypodermis. PCR/deficiency mapping of unc-23 (V), using sDf71 and mDf1 has narrowed down the region containing unc-23 to 14 cosmids. We are currently attempting transformation rescue of unc-23 using these cosmids.

    Affiliation:
    - Department of Zoology. University of British Columbia 6270 University Blvd. Vancouver, BC. Canada. V6T 1Z4


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