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Resources » Paper

Stephen E Von Stetina et al. (2002) West Coast Worm Meeting "In search of UNC-4 targets."

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    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00016755

    Stephen E Von Stetina, Peter J Roy, Stuart K Kim, & David M Miller III (2002). In search of UNC-4 targets presented in West Coast Worm Meeting. Unpublished information; cite only with author permission.

    Mutations in the UNC-4 homeodomain transcription factor disrupt backward locomotion. In unc-4 mutants, VA motor neurons fail to receive synapses from their usual interneuron partners and instead accept inputs normally reserved for their lineal sisters, the VB motor neurons. Work done in this laboratory has shown that UNC-4 and the Groucho homolog UNC-37 function together in VA motor neurons to repress VB-specific genes. GFP reporters constructed from three genes, del-1 (DEG/ENaC sodium channel subunit), acr-5 (nicotinic acetylcholine receptor subunit), and glr-41 (non-NMDA glutamate receptor subunit) are ectopically expressed in the VA motor neurons in unc-4 and unc-37 mutants. We have now performed genetic experiments, however, that rule out a necessary role for either ACR-5 or DEL-1 in the specification of VB-type inputs in both VA and VB neurons. The target genes that are responsible for synaptic choice have remained elusive, despite extensive genetic screens. We will now utilize a whole genome approach to identify the full complement of UNC-4 target genes and test those targets for a role in synaptogenesis.


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