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Resources » Paper

Goodwin EB et al. (1996) Worm Breeder's Gazette "laf-1 and translational repression of tra-2."

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    Status:
    Publication type:
    Gazette_article
    WormBase ID:
    WBPaper00015243

    Goodwin EB, & Kimble JE (1996). laf-1 and translational repression of tra-2. Worm Breeder's Gazette, 14(2), 56. Unpublished information; cite only with author permission.

    The sex determination gene tra-2 promotes female development; reduction of function mutations in tra-2 cause XX animals to be transformed into males. tra-2 activity must be repressed for male development to occur. Six dominant gain-of-function tra-2 mutations result in inappropriate feminization in both XX and XO animals: the germ line of tra-2(gf) XX animals produces only oocytes, and the intestine of tra-2(gf) XO animals makes yolk and the germ line oocytes. The tra-2(gf) mutations map to a 60 nt direct repeat located in the tra-2 3'UTR. The direct repeat controls the activity of tra-2 by repressing the translation of the tra-2 mRNA (Goodwin et al. 1993).

    Affiliation:
    - Northwestern University Medical School, Chicago Il. Howard Hughes Institute, University of Wisconsin, Madison Wisconsin


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