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Resources » Paper

Worby C et al. (2000) Sci STKE "Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5."

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  • Comments on Worby C et al. (2000) Sci STKE "Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5." (0)

  • Overview

    PMID:
    11752629
    DOI:
    10.1126/stke.2000.63.pe2
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00012959

    Worby C, & Margolis B (2000). Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5. Sci STKE, 2000, pe2. doi:10.1126/stke.2000.63.pe2

    Worby and Margolis highlight advances in our understanding of signaling from growth factor receptors using the worm Caenorhabditis elegans as a model organism. ARK-1, a cytoplasmic tyrosine kinase, appears to be a negative regulator of multiple pathways in C. elegans. The authors discuss several models for how this negative regulation may occur. The adaptor protein (Grb2 in mammals or SEM-5 in C. elegans) may serve as a regulated scaffold for the binding of other signaling proteins that include both positive (Ras) and negative (ACK) regulators. Thus, Grb2 may function in a cellular decision point for transducing the incoming signals.


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