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Resources » Paper

Sengupta P et al. (1993) Ciba Foundation Symposium "The cellular and genetic basis of olfactory responses in Caenorhabditis elegans."

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  • Comments on Sengupta P et al. (1993) Ciba Foundation Symposium "The cellular and genetic basis of olfactory responses in Caenorhabditis elegans." (0)

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    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00012124

    Sengupta P, Colbert HA, Kimmel BE, Dwyer ND, & Bargmann CI (1993). The cellular and genetic basis of olfactory responses in Caenorhabditis elegans. Ciba Foundation Symposium, discussion, 244-250.

    The small soil nematode Caenorhabditis elegans has only 302 neurons in its entire nervous system, so it is possible to analyse the functions of individual neurons in the animal's behaviour. We are using behavioural, cellular and genetic analyses of chemotactic responses to find out how olfactory behaviour patterns are generated and regulated. Single chemosensory neurons in C. elegans can recognize several different attractive odorants that are distinguished by the animal. Distinct sets of chemosensory neurons detect high and low concentrations of a single odorant. Odorant responses adapt after prolonged exposure to an odorant; this adaptation is odorant specific and reversible. Mutants with defects in odorant responses have been identified. Some genes appear to be necessary for the development or function of particular kinds of sensory neurons. Other genes have effects that suggest that they participate in odorant reception or signal transduction.

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