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Resources » Paper

Hisamoto N et al. (2000) Japanese Worm Meeting "The vab-22 gene is required for axis control in embryonic morphogenesis"

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    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00011905

    Hisamoto N, Matsumoto K, & Serizawa A (2000). The vab-22 gene is required for axis control in embryonic morphogenesis presented in Japanese Worm Meeting. Unpublished information; cite only with author permission.

    C. elegans morphogenesis is a complex process requiring numerous short-range migrations, rearrangements, and concerted cell movements. Several existing C. elegans mutants disrupt essential morphogenic events since they result in severe body deformities, classically described as a vab(variable-abnormal) phenotype. We have isolated novel vab-22 mutants. The vab-22 mutation is genetically mapped between unc-79 and unc-32 on LGIII. The body morphology in vab-22 is variably abnormal between the posterior end of pharynx and vulva. Ventral and dorsal nerve cord morphologies, in addition to alae and muscle morphologies, are also abnormal in this region. The vab-22(km6) mutant often exhibits abnormal morphogenesis during embryonic development and displays embryonic lethality. We examined the morphology of hypodermis in vab-22 embryos by using jam-1::GFP. At the beginning of morphogenesis, the morphology of vab-22 embryos seems to be normal. But, at 1.5-fold stage, they often twist and rotate laterally. These results suggest that vab-22 has a role to regulate the direction of dorsal-ventral axis in embryonic morphogenesis.


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