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Resources » Paper

Daulby J et al. (1996) European Worm Meeting "Glutathione-s-transferases of C.elegans"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00011732

    Daulby J, Isaac RE, & Coates D (1996). Glutathione-s-transferases of C.elegans presented in European Worm Meeting. Unpublished information; cite only with author permission.

    Glutathione-s-transferases (GSTs) are a large family of multifunctional enzymes involved in the detoxification and excretion of many physiological and xenobiotic substances in the cell. We are investigating the roles members of the sigma class of these enzymes may have in C.elegans in relation to their elimination of oxygen free radical damage which might contribute to cellular ageing. Initially we are examining expression pattern data in C.elegans lines transformed with LacZ reporter gene constructs containing predicted promoter regions of GST gene homologues. The predicted GST gene sequences were obtained from the genome sequencing project. All stages of development are being studied under a variety of environmental contditions to investigate GST gene expression inducibility, however particular attention will be paid to dauer stage larvae.

    Affiliation:
    - Dept of Biology, University of Leeds, Leeds. LS2 9JT UK


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