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Resources » Paper

Lints R et al. (2004) Dev Biol "Axial patterning of C. elegans male sensilla identities by selector genes."

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  • Comments on Lints R et al. (2004) Dev Biol "Axial patterning of C. elegans male sensilla identities by selector genes." (0)

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    PMID:
    15081363
    DOI:
    10.1016/j.ydbio.2004.01.021
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00006506

    Lints R, Jia L, Kim K, Li C, & Emmons SW (2004). Axial patterning of C. elegans male sensilla identities by selector genes. Dev Biol, 269, 137-51. doi:10.1016/j.ydbio.2004.01.021

    The fan and rays of the C. elegans male tail constitute a compound sensory organ essential for mating. Within this organ, the individual sensilla, known as rays, have unique identities. We show that ray identities are patterned by a selector gene mechanism in a manner similar to other serially homologous axial structures. One selector gene that promotes the identities of a subset of the rays is the Hox gene egl-5. Within EGL-5-expressing rays, further patterning is provided by a Pax-6 homolog and a signal of the TGFbeta family. These genes and pathway coordinately specify multiple ray properties affecting all three terminal ray cell types. These properties include complex patterns of FMRFamide-like (FaR-P) neuropeptides, serotonin (5HT) and dopamine expression, and ray morphology. Differences in these differentiated characteristics give each sensillum a unique identity and potentially endow the compound ray organ with a higher-order information


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