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Resources » Paper

Shen K et al. (2004) Cell "Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1."

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  • Comments on Shen K et al. (2004) Cell "Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1." (0)

  • Overview

    PMID:
    15035988
    DOI:
    10.1016/S0092-8674(04)00251-X
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00006489

    Shen K, Fetter RD, & Bargmann CI (2004). Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1. Cell, 116, 869-81. doi:10.1016/S0092-8674(04)00251-X

    Synaptic connections in the nervous system are directed onto specific cellular and subcellular targets. Synaptic guidepost cells in the C. elegans vulval epithelium drive synapses from the HSNL motor neuron onto adjacent target neurons and muscles. Here, we show that the transmembrane immunoglobulin superfamily protein SYG-2 is a central component of the synaptic guidepost signal. SYG-2 is expressed transiently by primary vulval epithelial cells during synapse formation. SYG-2 binds SYG-1, the receptor on HSNL, and directs SYG-1 accumulation and synapse formation to adjacent regions of HSNL. syg-1 and syg-2 mutants have defects in synaptic specificity; the HSNL neuron forms fewer synapses onto its normal targets and forms ectopic synapses onto inappropriate targets. Misexpression of SYG-2 in secondary epithelial cells causes aberrant accumulation of SYG-1 and synaptic markers in HSNL adjacent to the SYG-2-expressing cells. Our results indicate that local interactions between immunoglobulin superfamily proteins can determine specificity during


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