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Resources » Paper

Jee C et al. (2004) FEBS Lett "SHN-1, a Shank homologue in C. elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor."

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  • Comments on Jee C et al. (2004) FEBS Lett "SHN-1, a Shank homologue in C. elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor." (0)

  • Overview

    PMID:
    15013747
    DOI:
    10.1016/S0014-5793(04)00107-3
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00006456

    Jee C, Lee J, Lee JI, Lee WH, Park BJ, Yu JR, Park E, Kim E, & Ahnn J (2004). SHN-1, a Shank homologue in C. elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor. FEBS Lett, 561, 29-36. doi:10.1016/S0014-5793(04)00107-3

    Protein localization in the postsynaptic density (PSD) of neurons is mediated by scaffolding proteins such as PSD-95 and Shank, which ensure proper function of receptors at the membrane. The Shank family of scaffolding proteins contain PDZ (PSD-95, Dig, and ZO-1) domains and have been implicated in the localizations of many receptor proteins including glutamate receptors in mammals. We have identified and characterized shn-1, the only homologue of Shank in Caenorhahditis elegans. The shn-1 gene shows approximately 40% identity over 1000 amino acids to rat Shanks. SHN-1 protein is localized in various tissues including neurons, pharynx and intestine. RNAi suppression of SHN-1 did not cause lethality or developmental abnormality. However, suppression of SHN-1 in the itr-1 (sa73) mutant, which has a defective inositol-1,4,5-trisphosphate (IP3) receptor, resulted in animals with altered defecation rhythm. Our data suggest a possible role of SHN-1 in affecting function of IP3

    Authors: Jee C, Lee J, Lee JI, Lee WH, Park BJ, Yu JR, Park E, Kim E, Ahnn J


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