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Resources » Paper

Bolm M et al. (2004) Science "Bacterial resistance in daf-2 mutants."

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    PMID:
    15044786
    DOI:
    10.1126/science.303.5666.1976a
    Status:
    Publication type:
    Comment, Letter
    WormBase ID:
    WBPaper00006452

    Bolm M, Chhatwal GS, & Jansen WTM (2004). Bacterial resistance in daf-2 mutants. Science, 303, 1976; author reply 1976. doi:10.1126/science.303.5666.1976a

    In their Brevia "Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens," D.A. Garsin et al. show that long-lived C. elegans daf-2 mutants are resistant to killing by bacterial pathogens. Partial loss-of-function mutations in daf-2, which encodes an insulin-like receptor, results in de-repression of the transcription factor daf-16, leading to life extension and increased resistance to bacterial pathogens Enterococcus faecalis, Staphylococcus aureus, and Pseudomonas aeruginosa.


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