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Resources » Paper

Park FD et al. (2003) Development "Establishment of POP-1 asymmetry in early C. elegans embryos."

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  • Comments on Park FD et al. (2003) Development "Establishment of POP-1 asymmetry in early C. elegans embryos." (0)

  • Overview

    PMID:
    12810601
    DOI:
    10.1242/dev.00563
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00006044

    Park FD, & Priess JR (2003). Establishment of POP-1 asymmetry in early C. elegans embryos. Development, 130, 3547-56. doi:10.1242/dev.00563

    In Caenhorabtidis elegans embryos, the nuclei of sister cells that are born from anterior/posterior divisions show an invariant high/low asymmetry, respectively, in their level of the transcription factor POP-1. Previous studies have shown that POP-1 asymmetry between the daughters of an embryonic cell called EMS results in part from a Wnt-like signal provided by a neighboring cell, called P(2). We identify here additional signaling cells that play a role in POP-1 asymmetry for other early embryonic cells. Some of these cells have signaling properties similar to P(2), whereas other cells use apparently distinct signaling pathways. Although cell signaling plays a critical role in POP-1 asymmetry during the first few cell divisions, later embryonic cells have an ability to generate POP-1 asymmetry that appears to be independent of prior Wnt signaling.


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