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Resources » Paper

Wickens M et al. (2001) Cold Spring Harb Symp Quant Biol "PUF proteins and 3'UTR regulation in the Caenorhabditis elegans germ line."

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  • Comments on Wickens M et al. (2001) Cold Spring Harb Symp Quant Biol "PUF proteins and 3'UTR regulation in the Caenorhabditis elegans germ line." (0)

  • Overview

    PMID:
    12762036
    DOI:
    10.1101/sqb.2001.66.337
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00005771

    Wickens M, Bernstein D, Crittenden S, Luitjens C, & Kimble J (2001). PUF proteins and 3'UTR regulation in the Caenorhabditis elegans germ line. Cold Spring Harb Symp Quant Biol, 66, 337-43. doi:10.1101/sqb.2001.66.337

    In a simple and too common view, mRNAs are a dull milepost between DNA and protein in the Central Dogma. They acquire middling interest as guides for the ribosome, tRNAs, and translation factors. Yet mRNAs have lives of their own, lives that the cell cares about enormously. mRNAs are born, leave home, mate with ribosomes, produce proteins, and die, all as the cell sees fit. Powerful forces ? in the form of specific mRNA-binding proteins and their cohorts ? guide individual mRNAs into unique variations on this common path. These proteins govern mRNA stability, localization, and translation.


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