Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Yuan A et al. (2003) Neuron "The sodium-activated potassium channel is encoded by a member of the Slo gene family."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Yuan A et al. (2003) Neuron "The sodium-activated potassium channel is encoded by a member of the Slo gene family." (0)

  • Overview

    PMID:
    12628167
    DOI:
    10.1016/S0896-6273(03)00096-5
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00005750

    Yuan A, Santi CM, Wei A, Wang ZW, Pollak K, Nonet M, Kaczmarek L, Crowder CM, & Salkoff L (2003). The sodium-activated potassium channel is encoded by a member of the Slo gene family. Neuron, 37, 765-73. doi:10.1016/S0896-6273(03)00096-5

    Na+-activated potassium channels (K-Na) have been identified in cardiomyocytes and neurons where they may provide protection against ischemia. We now report that K-Na is encoded by the rSlo2 gene (also called Slack), the mammalian ortholog of slo-2 in C. elegans. rSlo2, heterologously expressed, shares many properties of native K-Na including activation by intracellular Na+, high conductance, and prominent subconductance states. In addition to activation by Na+, we report that rSLO-2 channels are cooperatively activated by intracellular Cl-, similar to C. elegans SLO-2 channels. Since intracellular Na+ and Cl- both rise in oxygen-deprived cells, coactivation may more effectively trigger the activity of rSLO-2 channels in ischemia. In C. elegans, mutational and physiological analysis revealed that the SLO-2 current is a major component of the delayed rectifier. We demonstrate in C. elegans that slo-2 mutants are hypersensitive to hypoxia, suggesting a conserved role for the slo-2 gene

    Authors: Yuan A, Santi CM, Wei A, Wang ZW, Pollak K, Nonet M, Kaczmarek L, Crowder CM, Salkoff L


    Tip: Seeing your name marked red? Please help us identify you.