Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Lerat E et al. (2002) J Mol Evol "Codon usage by transposable elements and their host genes in five species."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Lerat E et al. (2002) J Mol Evol "Codon usage by transposable elements and their host genes in five species." (0)

  • Overview

    PMID:
    11965435
    DOI:
    10.1007/s00239-001-0059-0
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00005220

    Lerat E, Capy P, & Biemont C (2002). Codon usage by transposable elements and their host genes in five species. J Mol Evol, 54, 625-37. doi:10.1007/s00239-001-0059-0

    We compared the codon usage of sequences of transposable elements (TEs) with that of host genes from the species Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Saccharomyces cerevisiae, and Homo sapiens. Factorial correspondence analysis showed that, regardless of the base composition of the genome, the TEs differed from the genes of their host species by their AT-richness. In all species, the percentage of A + T on the third codon position of the TEs was higher than that on the first codon position and lower than that in the noncoding DNA of the genomes. This indicates that the codon choice is not simply the outcome of mutational bias but is also subject to selection constraints. A tendency toward higher A + T on the third position than on the first position was also found in the host genes of A. thaliana, C. elegans, and S. cerevisiae but not in those of D. melanogaster and H. sapiens. This strongly suggests that the AT choice is a host-independent characteristic common to all TEs. The codon usage of TEs generally appeared to be different from the mean of the host acnes. In the AT-rich genomes of Arabidopsis thaliana, Caenorhabditis elegans, and Saccharomyces cerevisiae, the codon usage bias of TEs was similar to that of weakly expressed genes. In the GC-rich genome of D. melanogaster, however, the bias in codon usage of the TEs clearly differed from that of weakly expressed genes. These findings suggest that selection acts on TEs and that TEs may display specific behavior within the host genomes.


    Tip: Seeing your name marked red? Please help us identify you.