Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Wolkow CA (2002) Trends Neurosci "Life span: getting the signal from the nervous system."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Wolkow CA (2002) Trends Neurosci "Life span: getting the signal from the nervous system." (0)

  • Overview

    PMID:
    11998690
    DOI:
    10.1016/S0166-2236(02)02133-1
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00005170

    Wolkow CA (2002). Life span: getting the signal from the nervous system. Trends Neurosci, 25, 212-6. doi:10.1016/S0166-2236(02)02133-1

    Life span is determined by both environmental and genetic influences. The importance of genes is illustrated by the fact that single gene mutations extend life span in nematodes, fruit flies and mice. Recent reports reveal that the life span of Caenorhabditis elegans is controlled by insulin-like signals from the nervous system. Hormones that control life span have recently been identified in fruit flies and mice. These findings suggest that neuroendocrine pathways could constitute an important determinant of life span across phylogeny. This review examines the evidence for nervous system control of longevity and discusses the implications for popular models for aging.


    Tip: Seeing your name marked red? Please help us identify you.