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Resources » Paper

Lim CS et al. (2001) Curr Biol "C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p."

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  • Comments on Lim CS et al. (2001) Curr Biol "C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p." (0)

  • Overview

    PMID:
    11696330
    DOI:
    10.1016/S0960-9822(01)00526-7
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00004951

    Lim CS, Mian IS, Dernburg AF, & Campisi J (2001). C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr Biol, 11, 1706-10. doi:10.1016/S0960-9822(01)00526-7

    An important quest in modern biology is to identify genes involved in aging. Model organisms such as the nematode Caenorhabditis elegans are particularly useful in this regard. The C. elegans genome has been sequenced [1], and single gene mutations that extend adult life span have been identified [2]. Among these longevity-controlling loci are four apparently unrelated genes that belong to the clk family [3-5]. In mammals, telomere length and structure can influence cellular, and possibly organismal, aging [6]. Here, we show that clk-2 encodes a regulator of telomere length in C. elegans.


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