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Resources » Paper

Guarente L (2001) Trends Genet "SIR2 and aging--the exception that proves the rule."

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  • Overview

    PMID:
    11418219
    DOI:
    10.1016/S0168-9525(01)02339-3
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00004869

    Guarente L (2001). SIR2 and aging--the exception that proves the rule. Trends Genet, 17, 391-2. doi:10.1016/S0168-9525(01)02339-3

    One of the holy grails of medicine is the possibility of an increase in lifespan without a decrease in vitality. However, the causes and processes of human aging are still unclear. One evolutionary theory is that in the post-reproductive stage of life, selective forces decline allowing many vital systems to deteriorate. This suggests that intervention will be difficult, if not impossible. However, molecular geneticists propose an aging process that is programmed (like other developmental processes) and regulated by single genes, meaning that intervention could be possible. Here, I discuss a way of reconciling these two views that could have major implications for healthcare.


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