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Resources » Paper

Lin SX et al. (2001) Nat Cell Biol "Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells."

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  • Comments on Lin SX et al. (2001) Nat Cell Biol "Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells." (0)

  • Overview

    PMID:
    11389441
    DOI:
    10.1038/35078543
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00004830

    Lin SX, Grant B, Hirsh D, & Maxfield FR (2001). Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells. Nat Cell Biol, 3, 567-72. doi:10.1038/35078543

    RME-1 is an Eps15-homology (EH)-domain protein that was identified in a genetic screen for endocytosis gene in Caenorhabditis elegans. When expressed in a CHO cell line, the worm RME-1 protein and a mouse homologue are both associated with the endocytic recycling compartment. Here we show that expression of a dominant-negative construct with a point mutation near the EH domain results in redistribution of the endocytic recycling compartment and slowing down of transferrin receptor recycling. The delivery of a TGN38 chimaeric protein to the trans-Golgi network is also slowed down. The function of Rme-1 in endocytic recycling is evolutionarily conserved in metazoans as shown by the protein's properties in C. elegans.


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