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Resources » Paper

Das P et al. (1999) Cytokine Growth Factor Rev "Genetic approaches to TGFbeta signaling pathways."

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    PMID:
    10647775
    DOI:
    10.1016/S1359-6101(99)00014-3
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00003982

    Das P, Maduzia LL, & Padgett RW (1999). Genetic approaches to TGFbeta signaling pathways. Cytokine Growth Factor Rev, 10, 179-86. doi:10.1016/S1359-6101(99)00014-3

    In this review, we provide a summary of the genetic analysis of TGFBeta signal transduction, as well as its role in various human diseases and mouse models. We also use discoveries in the TGFBeta pathway as an example to highlight some of the techniques used in the invertebrate world of C. elegans and Drosophila to further our understanding of this, and other, signaling systems. The roles of such techniques in elucidating diverse pathways, as well as pathways of human disease genes, will become more important as the information from the genome projects increases and as the development of genetics tools to analyze them becomes more powerful. Given the conservation of signaling mechanisms, there will be increasing synergy between studies in invertebrates and vertebrates in future years for solving different cellular pathways.


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