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Resources » Paper

Copley RR et al. (1999) Curr Opin Struct Biol "Protein families in multicellular organisms."

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    PMID:
    10361098
    DOI:
    10.1016/S0959-440X(99)80055-4
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00003920

    Copley RR, Schultz J, Ponting CP, & Bork P (1999). Protein families in multicellular organisms. Curr Opin Struct Biol, 9, 408-15. doi:10.1016/S0959-440X(99)80055-4

    The complete sequence of the nematode worm Caenorhabditis elegans contains the genetic machinery that is required to undertake the core biological processes of single cells. However, the genome also encodes proteins that are associated with multicellularity, as well as others that are lineage-specific expansions of phylogenetically widespread families and yet more that are absent in non-nematodes. Ongoing analysis is beginning to illuminate the similarities and differences among human proteins and proteins that are encoded by the genomes of the multicellular worm and the unicellular yeast, and will be essential in determining the reliability of transferring experimental data among phylogenetically distant species.


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