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Resources » Paper

Cypser JR et al. (1999) Neurobiol Aging "The spe-10 mutant has longer life and increased stress resistance."

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  • Comments on Cypser JR et al. (1999) Neurobiol Aging "The spe-10 mutant has longer life and increased stress resistance." (0)

  • Overview

    PMID:
    10638523
    DOI:
    10.1016/S0197-4580(99)00085-8
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00003873

    Cypser JR, & Johnson TE (1999). The spe-10 mutant has longer life and increased stress resistance. Neurobiol Aging, 20, 503-12. doi:10.1016/S0197-4580(99)00085-8

    We investigated the life span of spe-10 mutant nematodes. We also tested resistance of spe-10 mutants to ultraviolet (UV) light, heat, and paraquat and examined the relationship between resistance to UV light and the fertility defect of these animals. The spe-10 mutation significantly increased mean life span. Additionally, the mutation significantly increased resistance to both UV light and to heat. Resistance to paraquat was not significantly different from that of wild-type, nor were any dauers formed at 27 degrees C. No significant correlation was found between the UV resistance and the fertility defect, nor was the UV resistance attributable to a hormetic effect. These results reinforce the importance of stress resistance in specifying increased life span and indirectly suggest that this fertility defect is not a direct cause of life span extension.


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