Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Conradt B et al. (1998) Cell "The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Conradt B et al. (1998) Cell "The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9." (0)

  • Overview

    PMID:
    9604928
    DOI:
    10.1016/S0092-8674(00)81182-4
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00003077

    Conradt B, & Horvitz HR (1998). The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell, 93, 519-29. doi:10.1016/S0092-8674(00)81182-4

    Gain-of-function mutations in the Caenorhabditis elegans gene egl-1 cause the HSN neurons to undergo programmed cell death. By contrast, a loss-of-function egl-1 mutation prevents most if not all somatic programmed cell deaths. The egl-1 gene negatively regulates the ced-9 gene, which protects against cell death and is a member of the bcl-2 family. The EGL-1 protein contains a nine amino acid region similar to the Bcl-2 homology region 3 (BH3) domain but does not contain a BH1, BH2, or BH4 domain, suggesting that EGL-1 may be a member of a family of cell death activators that includes the mammalian proteins Bik, Bid, Harakiri, and Bad. The EGL-1 and CED-9 proteins interact physically. We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex.


    Tip: Seeing your name marked red? Please help us identify you.