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Resources » Paper

Yuan JY (1997) Reprod Toxicol "Genetic control of cellular suicide."

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  • Overview

    PMID:
    9100313
    DOI:
    10.1016/S0890-6238(96)00150-5
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00002746

    Yuan JY (1997). Genetic control of cellular suicide. Reprod Toxicol, 11, 377-84. doi:10.1016/S0890-6238(96)00150-5

    Genetic analysis of programmed cell death in C. elegans has led to the identification of two genes, ced-9, a cell death suppressor, and ced-3, a cell death inducer, that play critical roles in regulating programmed cell death. The ced-9 and ced-3 genes were found to encode proteins that share structural and functional similarities with the mammalian proto-oncogene product Bcl-2 and interleukin-1 beta converting enzyme (ICE), respectively. Multiple members of the Bcl-2 family and the ICE family have been identified in vertebrates. These results suggest that the mechanism of apoptosis in vertebrates may be evolved from a much simpler version of a similar pathway in primitive organisms.


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