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Resources » Paper

Barnes TM et al. (1996) J Neurochem "The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein."

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  • Comments on Barnes TM et al. (1996) J Neurochem "The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein." (0)

  • Overview

    PMID:
    8667025
    DOI:
    10.1046/j.1471-4159.1996.67010046.x
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00002474

    Barnes TM, Jin YS, Horvitz HR, Ruvkun GB, & Hekimi S (1996). The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem, 67, 46-57. doi:10.1046/j.1471-4159.1996.67010046.x

    We report here the positional cloning and molecular characterization of the unc-24 gene of Caenorhabditis elegans. This gene is required for normal locomotion and interacts with genes that affect the worm's response to volatile anesthetics. The predicted gene product contains a domain similar to part of two ion channel regulators (the erythrocyte integral membrane protein stomatin and the C. elegans neuronal protein MEC-2) juxtaposed to a domain similar to nonspecific lipid transfer protein (nsLTP; also called sterol carrier protein 2). Sequence analysis suggests that the nsLTP-like domain of UNC-24 provides lipid carrier function and is tethered to the plasma membrane by the stomatin-like domain which may be regulatory. We postulate that UNC-24 may be involved in lipid transfer between closely apposed membranes.

    Affiliation:
    - Department of Biology, McGill University, Montreal, Quebec, Canada.

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